Talk about a comeback kid! With his career spanning over two decades, from the silver screen to made-for-TV movies to a primetime mega-hit, this seasoned actor-slash-married father of three has certainly dealt with his fair share of Hollywood ups and downs. Sure he`s played a teen hottie in Can’t Buy Me Love, and a debonair fiance in Sweet Home Alabama, but it was his turn as the most gorgeous neurosurgeon ever, .Dr. McDreamy, on Grey’s Anatomy that has definitely solidified his spot on the A-list. (His heartthrob good looks don`t hurt either)

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